Here are my tips, just finished it. I went with four created characters. You can use any companion and retrain them to your liking. I used 2 snipers, 2 brawlers, an assault(Kwon), and a pistol character(Lucia). Once you get to HQ(and have enough money) create a character for barter, weapon mods, and armor mods...no need to waste those skills on the main group. Just make sure every skill check field is covered by at least one member, and try to save those skill points until they are needed. I gave every character Animal Whisperer level 5 and took both perks...Animal Training/Spirit Animal. In the end game I had six+ followers helping in every battle, and I found it useful. Save skill books! Only use them on the 10th and final spot if possible since that rank takes 6 points. If I remember anything else I'll edit the post.
Sadomasochist/Vicious Avenger with Luck/Awareness/Intelligence maxed and building Charisma for high strike rate(2 on the other 3 attributes).
Skills: Sniper Rifles 10 Sneaky Shit 10
Perks: Masterful Precision and Concentration in the sniper tree and Lights out in the sneaky tree. This sniper would start every battle by targeting the biggest badass in the room first. Would often destroy the first target, then give initiative to the rest of the team so the enemies don't attack first.
Same but instead of Sneaky Shit I did 10 in Weird Science for the perks Microwave Research and Conductive Beams. Added a little Mechanics also to do more damage to machines.
Brawlers 1 and 2
Waste Roamer/Lethal Weapon with Strength/Coordination/Speed maxed...Charisma 4 or 5 then all Luck.
Skills: Brawling 10 for both then Nerd Stuff 10 on one and Animal Whisperer 10 on the other. They will have maximum movement with those attributes, so they can run around getting enemies to fight for the team.
Perks: Extreme Combo/Deadly Combo/Flurry of Blows...also if you have the skill points in leadership Rally works nicely at the start but you can put that on anyone other than the snipers.
Coordination/Awareness maxed...if you retrain him I would max Intelligence then add Charisma or Luck
Skills: Automatic Weapons 10
Perks: Double Tap/Trigger Happy
Coordination/Awareness maxed...if you retrain her I would max Intelligence then add Charisma or Luck
Skills: Small Arms 10 Explosives 10 (pistols have short range so she got the launcher)
Perks: Opportunist/Draw/High Impact/Blast Radius (Draw was rarely used so get that last if at all, unless you find a pistol with very small ammo count)
I think you can do everything in one play, but it would kinda ruin the game with all the planning. I think the best way to tackle this game is first play on Supreme Jerk...enjoy the game/strategy and see what happens. Then second play later following all the steps for cleanup on easiest setting. The Tourist difficulty is a walk in the park after playing Jerk...lol.