When you fight the last bosses(like Kyle 2, Mitch Corner, Mitch Corner from alternate universe and the Creatures from Satan) it is REALLY annoying, What I did was:
WHEN YOU START THE FIGHT, CHANGE DE COMBAT MODE TO CASUAL.....WHEN YOU ARE ABOUT TO WIN, CHANGE IT AGAIN TO MASTERMIND AND GIVE THE LAST PUNCH.....
It works for me.
I played only on mastermid, however the bosses was really pissing me off and i could`t handle, so i did this and worked.
REMEMBER THAT, like the other member said, to star the game on mastermind and DO THE THING THAT I SAID only on the final bosses.