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BioShock Hard mode tips


Legchomper

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Hey guys, I've started my Hard mode playthrough and was wondering if someone could just help me out with a few things. I know I need to research/hack everything and be cautious instead of going in guns blazing but there's some things I want to confirm:
 

1 - Should I harvest or save every little sister I encounter 
2 - Should I have them gather Adam from the enemies or just send them through the vent
3 - Although it varies for each person, is there a must upgrade for a specific weapon(s)
4 - Should I go exploring through every room for ammo/health/eve or just stick to the main objective

If anyone could help me, it would be a big help and appreciated, thanks. 

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